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Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
30455-1-PBS targets NLRC3 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | NLRC3 fusion protein Ag32323 相同性解析による交差性が予測される生物種 |
| Full Name | NLR family, CARD domain containing 3 |
| Calculated molecular weight | 115 kDa |
| Observed molecular weight | 100-110 kDa |
| GenBank accession number | NM_178844 |
| Gene Symbol | NLRC3 |
| Gene ID (NCBI) | 197358 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q7RTR2 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
NLRC3 is a member of the pattern recognition receptors nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) family, and plays a pivotal regulatory role in modulating the activation of immune cells. In macrophages, NLRC3 inhibits the activation of the NF-κB signaling pathway, the STING/TBK1 signaling pathway, and the formation of the inflammasome. In the context of T cells immune response, NLRC3 prevents the activation of T cells by regulating the function of dendritic cells and directly influencing the function of T cells.