Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
30455-1-PBS targets NLRC3 in WB, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | NLRC3 fusion protein Ag32323 相同性解析による交差性が予測される生物種 |
Full Name | NLR family, CARD domain containing 3 |
Calculated molecular weight | 115 kDa |
Observed molecular weight | 100-110 kDa |
GenBank accession number | NM_178844 |
Gene Symbol | NLRC3 |
Gene ID (NCBI) | 197358 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | Q7RTR2 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
NLRC3 is a member of the pattern recognition receptors nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) family, and plays a pivotal regulatory role in modulating the activation of immune cells. In macrophages, NLRC3 inhibits the activation of the NF-κB signaling pathway, the STING/TBK1 signaling pathway, and the formation of the inflammasome. In the context of T cells immune response, NLRC3 prevents the activation of T cells by regulating the function of dendritic cells and directly influencing the function of T cells.