CoraLite® Plus 488-conjugated Neuroserpin Monoclonal antibody

Neuroserpin Monoclonal Antibody for IF/ICC

Host / Isotype

Mouse / IgG1

Reactivity

human, rat, pig

Applications

IF/ICC

Conjugate

CoraLite® Plus 488 Fluorescent Dye

CloneNo.

1G4C6

Cat no : CL488-66997

Synonyms

Serpin I1, PI-12, PI12, PI 12, Peptidase inhibitor 12


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Tested Applications

Positive IF/ICC detected inU-251 cells

Recommended dilution

ApplicationDilution
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

CL488-66997 targets Neuroserpin in IF/ICC applications and shows reactivity with human, rat, pig samples.

Tested Reactivity human, rat, pig
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen Neuroserpin fusion protein Ag28636 相同性解析による交差性が予測される生物種
Full Name serpin peptidase inhibitor, clade I (neuroserpin), member 1
Calculated molecular weight 410 aa, 47 kDa
Observed molecular weight 46 kDa
GenBank accession numberBC018043
Gene symbol Neuroserpin
Gene ID (NCBI) 5274
Conjugate CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission maxima wavelengths493 nm / 522 nm
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Neuroserpin is a member of the serpin family of serine protease inhibitors predominantly expressed in the nervous system, such as s the cerebral cortex, hippocampus and the spinal cord.Neuroserpin exerts protective effects in neurons against excitotoxicity both in vitro and in vivo. Its proteolytic inhibitory activity is shown to protect neurons against damage caused by plasmin activation. Mice overexpressing neuroserpin exhibited loss of tPA activity in the brain. Overexpression of neuroserpin in primary neurons leads to increased dendritic arborization and altered dendritic spine shape.

Protocols

Product Specific Protocols
IF protocol for CL Plus 488 Neuroserpin antibody CL488-66997Download protocol
Standard Protocols
Click here to view our Standard Protocols