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OPA1 Monoclonal antibody, PBS Only
OPA1 Monoclonal Antibody for WB, IHC, ELISA
Host / Isotype
Mouse / IgG2b
Reactivity
Human, mouse, pig, rat
Applications
WB, IHC, ELISA
Conjugate
Unconjugated
CloneNo.
1B2D8
Cat no : 66583-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
66583-1-PBS targets OPA1 in WB, IHC, ELISA applications and shows reactivity with Human, mouse, pig, rat samples.
Tested Reactivity | Human, mouse, pig, rat |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Immunogen | OPA1 fusion protein Ag26868 相同性解析による交差性が予測される生物種 |
Full Name | optic atrophy 1 (autosomal dominant) |
Calculated molecular weight | 960 aa, 112 kDa |
Observed molecular weight | 100 kDa and 80-90 kDa |
GenBank accession number | BC075805 |
Gene symbol | OPA1 |
Gene ID (NCBI) | 4976 |
RRID | AB_2881943 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS only |
Storage Conditions | Store at -80°C. |
Background Information
OPA1 is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. OPA1 localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. OPA1 is associated with the inner membrane and protects cells from apoptosis by regulating inner membrane dynamics. Mutation of OPA1 causes the disease dominant optic atrophy, a degeneration of the retinal ganglion cells. OPA1 undergoes complex posttranscriptional regulation and posttranslational proteolysis. OPA1 is regulated by proteolytic cleavage, which degrades long OPA1 isoforms into short isoforms. The gene OPA1 can be cleaved into some chains with MW 100 kDa and 80-90 kDa.