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CoraLite®594-conjugated PGRMC1 Monoclonal antibody
PGRMC1 Monoclonal Antibody for IF
Host / Isotype
Mouse / IgG1
Reactivity
human, mouse, rat, pig
Applications
IF-P
Conjugate
CoraLite®594 Fluorescent Dye
CloneNo.
1C10D11
Cat no : CL594-66372
Synonyms
Validation Data Gallery
Tested Applications
Positive IF-P detected in | human ovary tumor tissue |
Recommended dilution
Application | Dilution |
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Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Product Information
CL594-66372 targets PGRMC1 in IF-P applications and shows reactivity with human, mouse, rat, pig samples.
Tested Reactivity | human, mouse, rat, pig |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | PGRMC1 fusion protein Ag3643 相同性解析による交差性が予測される生物種 |
Full Name | progesterone receptor membrane component 1 |
Calculated molecular weight | 195 aa, 22 kDa |
Observed molecular weight | 25-27 kDa |
GenBank accession number | BC034238 |
Gene symbol | PGRMC1 |
Gene ID (NCBI) | 10857 |
RRID | AB_2919983 |
Conjugate | CoraLite®594 Fluorescent Dye |
Excitation/Emission maxima wavelengths | 588 nm / 604 nm |
Form | Liquid |
Purification Method | Protein G purification |
Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
Storage Conditions | Store at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage. |
Background Information
Progesterone receptor membrane component 1 (PGRMC1) is a member of a multi-protein progesterone-binding complex. However, PGRMC1 shares homology with cytochrome b5-related proteins rather than hormone receptors (PMID: 18992768). It is a heme binding protein with biding sites for Src homology (SH2) and SH3 domain-containing proteins (PMID: 17583495). PGRMC1 is overexpressed in a variety of cancers, and thus represents an important biomarker for cancer progression and a potential target for anticancer drugs (PMID: 21730960). In nonmalignant tissues, PGRMC1 is highly expressed in the liver and kidney (PMID: 9705155; 20164297).
Protocols
Product Specific Protocols | |
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IF protocol for CL594 PGRMC1 antibody CL594-66372 | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |