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Phospho-p70(S6K) (Thr421/Ser424) Polyclonal antibody, PBS Only

Phospho-p70(S6K) (Thr421/Ser424) Polyclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 29248-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IF/ICC, Indirect ELISA

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -


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テクニカルサポートまたはご購入後1年間の交換/補填対応を承ります。詳細はこちらをご覧ください。


Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

29248-1-PBS targets Phospho-p70(S6K) (Thr421/Ser424) in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide 相同性解析による交差性が予測される生物種
Full Name ribosomal protein S6 kinase, 70kDa, polypeptide 1
Calculated molecular weight 59 kDa
Observed molecular weight65-85 kDa
GenBank accession numberBC053365
Gene Symbol p70 S6K
Gene ID (NCBI) 6198
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP23443
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

The Rps6kb1 gene encodes the 70 kDa ribosomal protein S6 kinase (p70S6K), which is a serine/threonine kinase regulated by phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway. P70S6K plays a crucial role in controlling cell cycle, growth and survival. The PI3K/mTOR signalling pathway is one of the major mechanisms for controlling cell survival, proliferation and metabolism and is the central regulator of translation of some components of protein synthesis system. Due to alternative translation two isoform S6K1 proteins are known to exist in mammalian cells: p85 S6K1 and p70 S6K1, which is identical to p85 S6K but lacks its first 23 amino acids. In addition, mammalian cells express a second S6K1 isoform spanning 316 amino acids (p31 S6K1). In the conventional model, Thr421/Ser424 sites are phosphorylated before Thr389 phosphorylation by mammalian target of rapamycin complex 1 (mTORC1) and subsequent Thr229 phosphorylation by PDK1. (PMID: 25100792, PMID: 24970012, PMID: 21602892)

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