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Thyroglobulin Monoclonal antibody

Thyroglobulin Monoclonal Antibody for IHC, IF-P, ELISA
Cat No. 60272-1-Ig
Clone No.4D3C5

Host / Isotype

Mouse / IgG2a

Reactivity

human and More (1)

Applications

IHC, IF-P, ELISA

TG, 4D3C5

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -


ご購入について

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国内在庫・納期について

約2万点のプロテインテック製品をコスモバイオ社物流センター(国内)に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。


保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換/補填対応を承ります。詳細はこちらをご覧ください。


Tested Applications

Positive IHC detected inhuman thyroid tissue, human thyroid cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF-P detected inhuman thyroid cancer tissue

Recommended dilution

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)-PIF-P : 1:200-1:800
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

60272-1-Ig targets Thyroglobulin in IHC, IF-P, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivityhuman, mouse
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen Thyroglobulin fusion protein Ag18070 相同性解析による交差性が予測される生物種
Full Name thyroglobulin
Calculated molecular weight 2768 aa, 305 kDa
GenBank accession numberBC140933
Gene Symbol Thyroglobulin
Gene ID (NCBI) 7038
RRIDAB_2881392
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP01266
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.

Protocols

Product Specific Protocols
IHC protocol for Thyroglobulin antibody 60272-1-IgDownload protocol
IF protocol for Thyroglobulin antibody 60272-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseIF

J Clin Endocrinol Metab

Identification of Eukaryotic Translation Initiation Factor 4B as a Novel Candidate Gene for Congenital Hypothyroidism

Authors - Feng Sun
humanIF

Front Immunol

Proteomics and Organoid Culture Reveal the Underlying Pathogenesis of Hashimoto's Thyroiditis.

Authors - Hui Xiao
humanIHC

Cancer Cell Int

Identification of an immune-related signature indicating the dedifferentiation of thyroid cells.

Authors - Xuemin Wang
humanIF

J Clin Endocrinol Metab

Somatic DICER1-Mutant Benign Thyroid Nodules in Adults: A Group of Follicular Nodular Disease With Continuous Growth

Authors - Lingyang Meng
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