Thyroglobulin Monoclonal antibody, PBS Only
Thyroglobulin Monoclonal Antibody for IHC, IF-P, Indirect ELISA
Host / Isotype
Mouse / IgG2a
Reactivity
human
Applications
IHC, IF-P, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
4D3C5
Cat no : 60272-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
60272-1-PBS targets Thyroglobulin in IHC, IF-P, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | Thyroglobulin fusion protein Ag18070 相同性解析による交差性が予測される生物種 |
| Full Name | thyroglobulin |
| Calculated molecular weight | 2768 aa, 305 kDa |
| GenBank accession number | BC140933 |
| Gene symbol | Thyroglobulin |
| Gene ID (NCBI) | 7038 |
| RRID | AB_2881392 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
