- Featured Product
- KD/KO Validated
TMEM173/STING Monoclonal antibody, PBS Only
TMEM173/STING Monoclonal Antibody for WB, IHC, ELISA
Host / Isotype
Mouse / IgG2b
Reactivity
Human, Rat
Applications
WB, IHC, ELISA
Conjugate
Unconjugated
CloneNo.
1F1E1
Cat no : 66680-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
66680-1-PBS targets TMEM173/STING in WB, IHC, ELISA applications and shows reactivity with Human, Rat samples.
Tested Reactivity | Human, Rat |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Immunogen | TMEM173/STING fusion protein Ag20363 相同性解析による交差性が予測される生物種 |
Full Name | transmembrane protein 173 |
Calculated molecular weight | 379 aa, 42 kDa |
Observed molecular weight | 37 kDa |
GenBank accession number | BC047779 |
Gene symbol | STING |
Gene ID (NCBI) | 340061 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS only |
Storage Conditions | Store at -80°C. |
Background Information
Stimulator of interferon genes (STING, also known as ERIS, MITA and MPYS, and encoded by TMEM173) is a transmembrane adaptor protein that facilitates innate immune signaling (PMID: 18724357). STING is widely expressed in various cell types such as endothelial cells, epithelial cells, T cells, macrophages, and dendritic cells (PMID: 26603901). It is predominantly located in the endoplasmic reticulum (ER). STING functions as a sensor of cytosolic DNA and promotes the production of type I interferons and pro-inflammatory cytokines. STING is a 379 amino acid protein with a calculated molecular weight of 42 kDa. It has been observed at 35-40 kDa (PMID: 27324217; 29632140; 30918080), and 70-80 kDa corresponding to the expected size of a STING dimer (PMID: 25790474; 29491158).