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TRPV4 Recombinant antibody, PBS Only

TRPV4 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Cat No. 84091-4-PBS
Clone No.241143H1

Host / Isotype

Rabbit / IgG

Reactivity

human, rat

Applications

WB, Indirect ELISA

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -


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保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換/補填対応を承ります。詳細はこちらをご覧ください。


Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

84091-4-PBS targets TRPV4 in WB, Indirect ELISA applications and shows reactivity with human, rat samples.

Tested Reactivity human, rat
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen TRPV4 fusion protein Ag27253 相同性解析による交差性が予測される生物種
Full Name transient receptor potential cation channel, subfamily V, member 4
Calculated molecular weight 98 kDa
Observed molecular weight 85~98 kDa
GenBank accession numberNM_001177428.1
Gene Symbol TRPV4
Gene ID (NCBI) 59341
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ9HBA0
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

TRPV4, also called VRL2 and VROAC, belongs to the transient receptor family and TrpV subfamily. It is a non-selective calcium permeant cation channel protein which involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. It is activated by low pH, citrate and phorbol esters. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Defects in TRPV4 are the cause of brachyolmia type 3 (BRAC3), spondylometaphyseal dysplasia Kozlowski type (SMDK) and metatropic dysplasia (MTD). Multiple transcript variants encoding different isoforms have been found.

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