Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
67249-1-PBS targets ULBP2 in WB, Indirect ELISA applications and shows reactivity with Human samples.
| Tested Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | ULBP2 fusion protein Ag28879 相同性解析による交差性が予測される生物種 |
| Full Name | UL16 binding protein 2 |
| Calculated molecular weight | 246 aa, 27 kDa |
| Observed molecular weight | 30-35 kDa |
| GenBank accession number | BC034689 |
| Gene Symbol | ULBP2 |
| Gene ID (NCBI) | 80328 |
| RRID | AB_2882526 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | Q9BZM5 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
NKG2D an activating cell surface receptor that is predominantly expressed on cytotoxic immune cells. NKG2D recognizes a wide range of ligands. In humans, the NKG2D ligand (NKG2DL) includes MICA, MICB, and six members of the ULBP family (ULBP1-6) (PMID: 29568297; 30813924). ULBPs are MHC class I-related molecules (PMID: 11239445). ULBP2 contains two Ig-like domains, the alpha-1 and alpha-2 domains characteristic of the MHC class I family, but lacks the alpha-3 domain. It can be expressed as either a transmembrane or GPI-linked protein, or released from the cell surface (PMID: 21224393; 24614922). ULBP2 binds and activates the NKG2D, mediating the recruitment and activation of NK cells.