Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
84877-5-PBS targets WAPL in WB, IHC, IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | WAPL fusion protein Ag9585 相同性解析による交差性が予測される生物種 |
Full Name | wings apart-like homolog (Drosophila) |
Calculated molecular weight | 142 kDa |
Observed molecular weight | 160-180 kDa |
GenBank accession number | BC017393 |
Gene Symbol | WAPL |
Gene ID (NCBI) | 23063 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
UNIPROT ID | Q7Z5K2 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
The wings apart-like (WAPL, or WAPAL) protein was originally identified as a gene product that potentially regulates heterochromatin organization in Drosophila melanogaster. Human WAPL is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. Overexpression of WAPL disturbs mitosis and cytokinesis, and contributes to tumor progression by induction of chromosomal instability. WAPAL has a predicted molecular weight of 140 kDa, however, as a result of its extensive phosphorylation it separates on a SDS gel as a band of approximately 160-180 kDa.