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Beta Arrestin 1 Monoclonal antibody

Beta Arrestin 1 Monoclonal Antibody for WB, IHC, ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human, mouse, rat

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

CloneNo.

1H8E4

Cat no : 67580-1-Ig

Synonyms

ARRB1, ARR1, ARR 1, ARB2, ARB1


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Tested Applications

Positive WB detected inHepG2 cells, HeLa cells, NIH/3T3 cells, human peripheral blood platelets, K-562 cells, Jurkat cells, HSC-T6 cells
Positive IHC detected inmouse brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:2000-1:10000
Immunohistochemistry (IHC)IHC : 1:250-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

67580-1-Ig targets Beta Arrestin 1 in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen Beta Arrestin 1 fusion protein Ag7504 相同性解析による交差性が予測される生物種
Full Name arrestin, beta 1
Calculated molecular weight 47 kDa
Observed molecular weight 45-55 kDa
GenBank accession numberBC003636
Gene symbol Beta Arrestin 1
Gene ID (NCBI) 408
RRIDAB_2882791
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

β-Arrestins (ARRBs), the best known regulators of G protein-coupled receptor signaling, are versatile and multifunctional adapter proteins that regulate diverse cellular functions, including cell growth, apoptosis and immune responses. Overexpression of beta Arrestin 1 has been found in various cancers, indicating it as a potential therapeutic target for cancer treatment. Recently expression of ARRB1 in saliva has been identified as a candidate circadian biomarker. ARRB1 migrated as a doublet of two bands of 45 and 55 kDa (PMID:28947386).

Protocols

Product Specific Protocols
WB protocol for Beta Arrestin 1 antibody 67580-1-IgDownload protocol
IHC protocol for Beta Arrestin 1 antibody 67580-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols