p504S,AMACR Monoclonal antibody, PBS Only
p504S,AMACR Monoclonal Antibody for WB, IF/ICC, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
human, mouse, rat
Applications
WB, IF/ICC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
2H9B5
Cat no : 60240-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
60240-1-PBS targets p504S,AMACR in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Reactivity | human, mouse, rat |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | p504S,AMACR fusion protein Ag8720 相同性解析による交差性が予測される生物種 |
Full Name | alpha-methylacyl-CoA racemase |
Calculated molecular weight | 382 aa, 42 kDa |
Observed molecular weight | 42 kDa |
GenBank accession number | BC009471 |
Gene symbol | AMACR |
Gene ID (NCBI) | 23600 |
RRID | AB_2881363 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
AMACR(Alpha-methyl acyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing. Defects in AMACR are the cause of alpha-methyl acyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4).