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uPAR/CD87 Monoclonal antibody

uPAR/CD87 Monoclonal Antibody for WB, IHC, ELISA
Cat No. 68727-1-Ig
Clone No.2A3E8

Host / Isotype

Mouse / IgG2b

Reactivity

human

Applications

WB, IHC, ELISA

uPAR, PLAUR, PLAUR, UPAR, U PAR, MO3

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -


ご購入について

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国内在庫・納期について

約2万点のプロテインテック製品をコスモバイオ社物流センター(国内)に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。


保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換/補填対応を承ります。詳細はこちらをご覧ください。


Tested Applications

Positive WB detected inU2OS cells, U-251 cells, A549 cells
Positive IHC detected inhuman lung squamous cell cancer
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:4000
Immunohistochemistry (IHC)IHC : 1:250-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

68727-1-Ig targets uPAR/CD87 in WB, IHC, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen uPAR/CD87 fusion protein Ag28056 相同性解析による交差性が予測される生物種
Full Name PLAUR
Calculated molecular weight 37 kDa
Observed molecular weight35-50 kDa
GenBank accession numberBC002788
Gene Symbol uPAR
Gene ID (NCBI) 5329
RRIDAB_3670419
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ03405
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

uPAR is a highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)

Protocols

Product Specific Protocols
WB protocol for uPAR/CD87 antibody 68727-1-IgDownload protocol
IHC protocol for uPAR/CD87 antibody 68727-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols
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