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Validation Data Gallery

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  • Western Blot (WB) analysis of U2OS cells using uPAR/CD87 Monoclonal antibody (68727-1-Ig)

    WB analysis of U2OS using 68727-1-Ig (same clone as 68727-1-PBS)

    U2OS cells were subjected to SDS PAGE followed by western blot with 68727-1-Ig (uPAR/CD87 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68727-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using uPAR/CD87 Monoclonal antibody (68727-1-Ig)

    WB analysis using 68727-1-Ig (same clone as 68727-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68727-1-Ig (uPAR, PLAUR antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68727-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human lung squamous cell cancer using uPAR/CD87 Monoclonal antibody (68727-1-Ig)

    IHC staining of human lung squamous cell cancer using 68727-1-Ig (same clone as 68727-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung squamous cell cancer slide using 68727-1-Ig (uPAR/CD87 antibody) at dilution of 1:500 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 68727-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human lung squamous cell cancer using uPAR/CD87 Monoclonal antibody (68727-1-Ig)

    IHC staining of human lung squamous cell cancer using 68727-1-Ig (same clone as 68727-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung squamous cell cancer slide using 68727-1-Ig (uPAR/CD87 antibody) at dilution of 1:500 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 68727-1-PBS in a different storage buffer formulation.

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uPAR/CD87 Monoclonal antibody, PBS Only

uPAR/CD87 Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 68727-1-PBS
Clone No.2A3E8

Host / Isotype

Mouse / IgG2b

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Synonyms

uPAR, PLAUR, PLAUR, UPAR, U PAR, MO3

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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約2万点のプロテインテック製品をコスモバイオ社物流センター（国内）に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。

保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

68727-1-PBS targets uPAR/CD87 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen uPAR/CD87 fusion protein Ag28056 相同性解析による交差性が予測される生物種
Full Name PLAUR
Calculated molecular weight 37 kDa
Observed molecular weight35-50 kDa
GenBank accession numberBC002788
Gene Symbol uPAR
Gene ID (NCBI) 5329
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ03405
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

uPAR is a highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)