uPAR/CD87 Recombinant antibody, PBS Only (Capture/Detector)
uPAR/CD87 Recombinant Antibody for WB, IHC, Cytometric bead array, Sandwich ELISA, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
WB, IHC, Cytometric bead array, Sandwich ELISA, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
230148B10
Cat no : 82953-2-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
82953-2-PBS targets uPAR/CD87 as part of a matched antibody pair:
MP00129-1: 82953-2-PBS capture and 82953-3-PBS detection (validated in Sandwich ELISA)
MP00129-2: 82953-4-PBS capture and 82953-2-PBS detection (validated in Cytometric bead array, Sandwich ELISA)
Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | uPAR/CD87 fusion protein Ag28056 相同性解析による交差性が予測される生物種 |
| Full Name | PLAUR |
| Calculated molecular weight | 37 kDa |
| Observed molecular weight | 35-50 kDa |
| GenBank accession number | BC002788 |
| Gene symbol | uPAR |
| Gene ID (NCBI) | 5329 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| Storage Buffer | 100% PBS pH 7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
uPAR is a highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)
