CoraLite® Plus 488-conjugated ACVR1 Monoclonal antibody
ACVR1 Monoclonal Antibody for IF-P
Host / Isotype
Mouse / IgG2a
Reactivity
Human, Mouse
Applications
IF-P
Conjugate
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
1F11B10
Cat no : CL488-67417
Synonyms
Validation Data Gallery
Tested Applications
| Positive IF-P detected in | mouse brain tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
CL488-67417 targets ACVR1 in IF-P applications and shows reactivity with Human, Mouse samples.
| Tested Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | ACVR1 fusion protein Ag13508 相同性解析による交差性が予測される生物種 |
| Full Name | activin A receptor, type I |
| Calculated molecular weight | 509 aa, 57 kDa |
| GenBank accession number | BC033867 |
| Gene symbol | ACVR1 |
| Gene ID (NCBI) | 90 |
| RRID | AB_2919468 |
| Conjugate | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Purification Method | Protein A purification |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
ACVR1 (activin receptor type I), also known as ALK2 or ACTRI, is a receptor for activin. It forms a stable complex with type II receptor after ligand binding. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. ACVR1 is expressed in many tissues including skeletal muscle and chondrocytes. It functions as a receptor for bone morphogenetic protein (BMP) and induces Indian hedgehog in chondrocytes during skeletal development. Mutations in ACVR1 gene are associated with fibrodysplasia ossificans progressive (PMID: 16642017).
Protocols
| Product Specific Protocols | |
|---|---|
| IF protocol for CL Plus 488 ACVR1 antibody CL488-67417 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
