CoraLite®594-conjugated ACVR1 Monoclonal antibody
ACVR1 Monoclonal Antibody for IF
Host / Isotype
Mouse / IgG2a
Reactivity
Human, Mouse
Applications
IF-P
Conjugate
CoraLite®594 Fluorescent Dye
CloneNo.
1F11B10
Cat no : CL594-67417
Synonyms
Validation Data Gallery
Tested Applications
Positive IF-P detected in | mouse brain tissue |
Recommended dilution
Application | Dilution |
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Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Product Information
CL594-67417 targets ACVR1 in IF-P applications and shows reactivity with Human, Mouse samples.
Tested Reactivity | Human, Mouse |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Immunogen | ACVR1 fusion protein Ag13508 相同性解析による交差性が予測される生物種 |
Full Name | activin A receptor, type I |
Calculated molecular weight | 509 aa, 57 kDa |
GenBank accession number | BC033867 |
Gene symbol | ACVR1 |
Gene ID (NCBI) | 90 |
RRID | AB_2920130 |
Conjugate | CoraLite®594 Fluorescent Dye |
Excitation/Emission maxima wavelengths | 588 nm / 604 nm |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
Storage Conditions | Store at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage. |
Background Information
ACVR1 (activin receptor type I), also known as ALK2 or ACTRI, is a receptor for activin. It forms a stable complex with type II receptor after ligand binding. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. ACVR1 is expressed in many tissues including skeletal muscle and chondrocytes. It functions as a receptor for bone morphogenetic protein (BMP) and induces Indian hedgehog in chondrocytes during skeletal development. Mutations in ACVR1 gene are associated with fibrodysplasia ossificans progressive (PMID: 16642017).
Protocols
Product Specific Protocols | |
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IF protocol for CL594 ACVR1 antibody CL594-67417 | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |