CoraLite® Plus 488-conjugated ADRM1 Monoclonal antibody
ADRM1 Monoclonal Antibody for IF
Host / Isotype
Mouse / IgG3
Reactivity
human
Applications
IF/ICC
Conjugate
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
1A1A3
Cat no : CL488-66464
Synonyms
Validation Data Gallery
Tested Applications
Positive IF/ICC detected in | HeLa cells |
Recommended dilution
Application | Dilution |
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Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Product Information
CL488-66464 targets ADRM1 in IF/ICC applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG3 |
Class | Monoclonal |
Type | Antibody |
Immunogen | ADRM1 fusion protein Ag24699 相同性解析による交差性が予測される生物種 |
Full Name | adhesion regulating molecule 1 |
Calculated molecular weight | 407 aa, 42 kDa |
Observed molecular weight | 42 kDa |
GenBank accession number | BC017245 |
Gene symbol | ADRM1 |
Gene ID (NCBI) | 11047 |
Conjugate | CoraLite® Plus 488 Fluorescent Dye |
Excitation/Emission maxima wavelengths | 493 nm / 522 nm |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
The 26S proteasome is a key component of the ubiquitin-proteasome system, a process responsible for the majority of cellular protein degradation. hRpn13 (also termed ADRM1 or GP110) is a novel 46-kDa subunit of its 19S regulatory complex. hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity. Overexpression of hRpn13 promotes the activity of the ubiquitin-proteasome system and modulates the influence of osteoblasts on osteoclasts by controlling the stability of regulatory proteins in osteoblasts.
Protocols
Product Specific Protocols | |
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IF protocol for CL Plus 488 ADRM1 antibody CL488-66464 | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |