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- KD/KO Validated
PE-conjugated ASGR1 Monoclonal antibody
ASGR1 Monoclonal Antibody for IF-P
Host / Isotype
Mouse / IgG1
Reactivity
human, mouse, rat, pig
Applications
IF-P
Conjugate
PE Fluorescent Dye
CloneNo.
1G5F5
Cat no : PE-66692
Synonyms
Validation Data Gallery
Tested Applications
| Positive IF-P detected in | rat liver tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
PE-66692 targets ASGR1 in IF-P applications and shows reactivity with human, mouse, rat, pig samples.
| Tested Reactivity | human, mouse, rat, pig |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | ASGR1 fusion protein Ag2310 相同性解析による交差性が予測される生物種 |
| Full Name | asialoglycoprotein receptor 1 |
| Calculated molecular weight | 291 aa, 33 kDa |
| Observed molecular weight | 42-46 kDa |
| GenBank accession number | BC032130 |
| Gene symbol | ASGR1 |
| Gene ID (NCBI) | 432 |
| Conjugate | PE Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 496 nm, 565 nm / 578 nm |
| Form | Liquid |
| Purification Method | Protein G purification |
| Storage Buffer | PBS with 0.1% sodium azide and 0.5% BSA. |
| Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
Background Information
Asialoglycoprotein receptor (ASGPR), also known as the hepatic galactose/N-acetylglucosamine (GlcNAc) receptor or Ashwell receptor, is a C-type lectin expressed exclusively in hepatic parenchymal cells. ASGPR consists of two subunits, a major subunit (ASGR1, HL-1) and a minor subunit (ASGR2, HL-2), and specifically recognizes terminal β-linked galactose or GlcNAc on circulating glycoproteins or cells. This receptor plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins that contain terminal galactose or GlcNAc residues. ASGPR may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery.
Protocols
| Product Specific Protocols | |
|---|---|
| IF protocol for PE ASGR1 antibody PE-66692 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
