☆ 3/31(月)まで!二次抗体 & FlexAbleが30%オフ! >> 免疫アッセイサポートキャンペーン

  • Featured Product
  • KD/KO Validated

IFITM2-Specific Monoclonal antibody

IFITM2-Specific Monoclonal Antibody for WB, ELISA
Cat No. 66137-1-Ig
Clone No.3D5F7

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

WB, IHC, IF, ELISA

IFITM2, IFITM 2, DSPA2c, 3D5F7, 18D

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Unconjugated
CoraLite® Plus 488
Size/Concentration: 

-/ -


ご購入について

国内販売は「コスモ・バイオ株式会社」を通じて行っております。お見積り・ご注文はお近くの販売代理店へご連絡ください。


国内在庫・納期について

約2万点のプロテインテック製品をコスモバイオ社物流センター(国内)に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。


保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換/補填対応を承ります。詳細はこちらをご覧ください。


Tested Applications

Positive WB detected inHepG2 cells, recombinant protein

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

66137-1-Ig targets IFITM2-Specific in WB, IHC, IF, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivityhuman
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen Recombinant protein 相同性解析による交差性が予測される生物種
Full Name interferon induced transmembrane protein 2 (1-8D)
Observed molecular weight 15 kDa
GenBank accession numberNM_006435
Gene Symbol IFITM2
Gene ID (NCBI) 10581
RRIDAB_2881536
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ01629
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

IFITM2, also named as 1-8D, belongs to the CD225 family. It is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. IFITM2 induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. It is overexpressed in colon carcinoma. IFITM2 is a novel pro-apoptotic gene that will provide new insights into the regulated cellular pathways to death.(PMID:19544527) This antibody is specific to IFTIM2.

Protocols

Product Specific Protocols
WB protocol for IFITM2-Specific antibody 66137-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Cell

Intrinsic Immunity Shapes Viral Resistance of Stem Cells.

Authors - Xianfang Wu
  • KO Validated
humanWB

Proc Natl Acad Sci U S A

Δ20 IFITM2 differentially restricts X4 and R5 HIV-1.

Authors - Wan-Lin Wu
humanWB

EMBO J

Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells.

Authors - Blandine Monel
humanWB

Proc Natl Acad Sci U S A

mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3.

Authors - Guoli Shi
human

Mol Cell Proteomics

HIV-1 Nef changes the proteome of T cells extracellular vesicles depleting IFITMs and other antiviral factors

Authors - Mara E da Silva-Januário
humanWB

PLoS Pathog

p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication.

Authors - Xin Wang
  • KD Validated
Loading...