CoraLite® Plus 647-conjugated RYR2 Polyclonal antibody
RYR2 Polyclonal Antibody for IF-P
Host / Isotype
Rabbit / IgG
Reactivity
Human, mouse
Applications
IF-P
Conjugate
CoraLite® Plus 647 Fluorescent Dye
Cat no : CL647-27587
Synonyms
Validation Data Gallery
Tested Applications
| Positive IF-P detected in | mouse heart tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
CL647-27587 targets RYR2 in IF-P applications and shows reactivity with Human, mouse samples.
| Tested Reactivity | Human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | RYR2 fusion protein Ag26296 相同性解析による交差性が予測される生物種 |
| Full Name | ryanodine receptor 2 (cardiac) |
| Calculated molecular weight | 565 kDa |
| GenBank accession number | NM_001035 |
| Gene symbol | RYR2 |
| Gene ID (NCBI) | 6262 |
| Conjugate | CoraLite® Plus 647 Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 654 nm / 674 nm |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
RYR2 belongs to the ryanodine receptor family. RYR2 provides communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Defects in RYR2 are the cause of familial arrhythmogenic right ventricular dysplasia type 2 (ARVD2) which known as arrhythmogenic right ventricular cardiomyopathy 2 (ARVC2). Defects in RYR2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) which known as stress-induced polymorphic ventricular tachycardia (VTSIP).
Protocols
| Product Specific Protocols | |
|---|---|
| IF protocol for CL Plus 647 RYR2 antibody CL647-27587 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
