CoraLite® Plus 488-conjugated SERPING1/C1 Inactivator Polyclonal antibody
SERPING1/C1 Inactivator Polyclonal Antibody for IF/ICC
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse
Applications
IF/ICC
Conjugate
CoraLite® Plus 488 Fluorescent Dye
Cat no : CL488-12259
Synonyms
Validation Data Gallery
Tested Applications
| Positive IF/ICC detected in | HepG2 cells |
Recommended dilution
| Application | Dilution |
|---|---|
| Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
CL488-12259 targets SERPING1/C1 Inactivator in IF/ICC applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | SERPING1/C1 Inactivator fusion protein Ag2819 相同性解析による交差性が予測される生物種 |
| Full Name | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 |
| Calculated molecular weight | 500 aa, 55 kDa |
| Observed molecular weight | 100 kDa |
| GenBank accession number | BC011171 |
| Gene symbol | SERPING1 |
| Gene ID (NCBI) | 710 |
| Conjugate | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
SERPING1, also known as C1 Inhibitor (C1INH), is a member of the Serine proteinase inhibitor family. Its main function is the inhibition of the complement system to prevent spontaneous activation. It inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). C1INH is the most heavily glycosylated plasma protein. Of its 95-105 kDa apparent molecular mass, the protein moiety of 500 aa accounts for only 55 kDa. The native 105 kDa form of C1INH could be cleaved into 60-65 kDa fragments.
Protocols
| Product Specific Protocols | |
|---|---|
| IF protocol for CL Plus 488 SERPING1/C1 Inactivator antibody CL488-12259 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
