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コロナウイルス （COVID-19） 関連製品

コロナウイルス（COVID-19）の研究、製品、その他関連情報

新型コロナウイルス感染症（COVID-19）の背景

新型コロナウイルス感染症 （COVID-19）は、重症急性呼吸器症候群コロナウイルス2 （SARS-CoV-2）に起因する感染症です。 コロナウイルスという名前は、その光輪のような外観を指し、顕微鏡で見たときにウイルス粒子の周囲には「太陽コロナ（光冠）」に視覚的に似た形態を確認できます。

新型コロナウイルスの細胞への侵入

左図はHeurichらによるJournal of Virology誌に掲載された論文の図を改変したものです（PMID：24227843）

 

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SARS-COV-2の感染機構としてNEUROPILIN-1がACE2に加わる

カタログ番号 製品名 アプリケーション 交差種 文献数
80063-1-RR ACE2 Recombinant Antibody IHC, ELISA Human  
21115-1-AP Human ACE2 Polyclonal Antibody IHC, WB, IP Human, Mouse, Rat 71
28868-1-AP Human ACE2 Polyclonal Antibody WB, IHC, IF, ELISA Human, Mouse, Rat  
66699-1-Ig Human ACE2 Monoclonal Antibody IHC, WB Human, Mouse 17
Ag30683 ACE2 (Binding domain) Fusion Protein      
Ag15554 ACE2 (C-terminal) Fusion Protein      
14437-1-AP Human TMPRSS2 Polyclonal Antibody IHC, WB Human, Mouse, Rat 15
18413-1-AP Human FURIN Polyclonal Antibody WB, IP, IHC, ELISA Human, Mouse, Rat 10
67481-1-Ig Human FURIN Monoclonal Antibody WB, IHC, ELISA Human  
60067-1-Ig Neuropilin 1 Monoclonal antibody WB, IF, FC, ELISA Human, Pig 10
11739-1-AP ASGR1 Polyclonal antibody WB, IP, IHC, IF, FC, ELISA Human, Mouse, Rat 10
66692-1-Ig ASGR1 Monoclonal antibody WB, ELISA Human, Mouse, Pig  
Ag2310 ASGR1 Fusion Protein      

カタログ番号 製品名 ターゲットドメイン 免疫原 備考／アプリケーション 文献数
28901-1-AP SARS-COV-2 Spike protein (428-506aa) Polyclonal Antibody 428-506aa Ag30684 SARS-COV-2 S protein specific  
28869-1-AP SARS-COV-2 Spike protein (126-264aa) Polyclonal Antibody 126-264aa Ag30685 SARS-COV-2 S protein specific  
28867-1-AP SARS-COV-2 Spike protein (944-1214aa) Polyclonal Antibody 944-1214aa Ag30679 For SARS/SARS-COV-2/MERS 1
67758-1-Ig SARS-COV-2 Spike Glycoprotein (319-541 aa) 319-541aa Ag30688 WB, Neutralization, ELISA  
28769-1-AP SARS-COV-2 Nucleocapsid Phosphoprotein Polyclonal Antibody 1-419aa Ag30676 WB, ELISA 1
28882-1-AP SARS-COV-2 Membrane Protein Glycoprotein Polyclonal Antibody 100-222aa Ag30691 ELISA  
28904-1-AP SARS-COV-2 Envelope Protein Polyclonal Antibody 1-75aa Ag30690 ELISA  
67666-1-Ig SARS-COV-2 Nucleocapsid Phosphoprotein Monoclonal Antibody 1-419aa Ag30676 WB, ELISA 1
67666-2-Ig SARS-COV-2 Nucleocapsid Phosphoprotein Monoclonal Antibody 1-419aa Ag30676 WB, ELISA  
80026-1-RR SARS-COV-2 Nucleocapsid Phosphoprotein Recombinant Antibody 1-419aa Ag30676  *NEW*  
80027-1-RR SARS-COV-2 Nucleocapsid Phosphoprotein Recombinant Antibody 1-419aa Ag30676  *NEW*  
29287-1-AP SARS-COV-2 NSP1 Polyclonal antibody 1-180aa Ag30935 ELISA  
29286-1-AP SARS-COV-2 NSP5 Polyclonal antibody 1-306aa Ag30934 ELISA  
29263-1-AP SARS-COV-2 NSP7 Polyclonal antibody 1-83aa Ag30933 ELISA  
29262-1-AP SARS-COV-2 NSP8 Polyclonal antibody 1-198aa Ag30932 ELISA  
29264-1-AP SARS-COV-2 NSP12 Polyclonal antibody 1-200aa Ag30931 ELISA  
29467-1-AP SARS-COV-2 NSP13 Polyclonal antibody 318-469aa Ag30930 ELISA  
29301-1-AP SARS-COV-2 NSP15 Polyclonal antibody 1-346aa Ag30929 ELISA  

 

 

カタログ番号 製品名 アプリケーション 交差種 文献数
60099-1-Ig Human IgA Monoclonal Antibody WB, IHC, IF, ELISA Human 1
66484-1-Ig Human IgM Monoclonal Antibody WB, IHC, IF Human 1
CL488-66484 CL488-human IgM Monoclonal Antibody WB, IHC, IF Human 2
CL594-66484 CL594-human IgM Monoclonal Antibody WB, IHC, IF Human  
11016-1-AP Human IgM Polyclonal Antibody WB, IHC Human 1
10284-1-AP Rabbit Anti-Human IgG WB, IHC Human 4
HRP-66484 HRP-Conjugated Human IgM Antibody WB, ELISA Human  

 

 

カタログ番号 製品名 アプリケーション 交差種 文献数
CL488-66211 Human CD13 Monoclonal Antibody IF Human  
14553-1-AP Human CD13 Polyclonal Antibody FC, IF, IHC, WB Human, Mouse, Rat 5
CL594-66211 CL594-Human CD13 Monoclonal Antibody IF Human  
66211-1-Ig Human CD13 Monoclonal Antibody IF, IHC, WB, Human 5
CL488-14553 CL488-Human CD13 Polyclonal Antibody IF Human, Mouse, Rat  
66443-1-Ig Human CD147 Monoclonal Antibody IHC, WB Human, Pig 4
CL594-66443 CL594-Human CD147 Monoclonal Antibody IF Human, Pig  
11989-1-AP Human CD147 Polyclonal Antibody IHC, IP, WB, Human, Mouse 19
CL488-66443 CL488-Human CD147 Monoclonal Antibody FC, IF,  Human, Pig  
21115-1-AP Human ACE2 Polyclonal Antibody IHC, IP, WB,  Human, Mouse, Rat 71
66699-1-Ig Human ACE2 Monoclonal Antibody IHC, WB Human 17
20597-1-AP Human CD9 Polyclonal Antibody IHC, WB, FC Human, Pig 94
60232-1-Ig Human CD9 Monoclonal Antibody WB, IHC Human, Rat 26
60067-1-Ig Neuropilin 1 Monoclonal Antibody WB, IF, FC, ELISA Human, Pig, Xenopus 10
11739-1-AP ASGR1 Polyclonal antibody FC, IF, IHC, IP, WB, ELISA Human, Mouse, Rat 10
CL488-11739 CoraLite®488-conjugated ASGR1 Polyclonal antibody FC, IF Human, Mouse, Rat  
CL594-11739 CoraLite®594-conjugated ASGR1 Polyclonal antibody IF Human, Mouse, Rat  
66692-1-Ig ASGR1 Monoclonal antibody WB, ELISA Human, Mouse, Pig  

 

カタログ番号 製品名 アプリケーション 交差種 文献数
66670-1-Ig Human IRF3 Monoclonal Antibody IHC, WB Human 2
11312-1-AP Human IRF3 Polyclonal Antibody FC, IF, IHC, IP, WB Human, Mouse, Rat 85
22392-1-AP Human IRF7 Polyclonal Antibody IHC, IP, WB Human 7
23230-1-AP Human MYD88 Polyclonal Antibody WB Human 96
66992-1-Ig Human NFKB1 Monoclonal Antibody IF, WB Human 1
14220-1-AP Human NF-κB Polyclonal Antibody IF, IP, WB Human, Rat 132
15506-1-AP Human NFKB1,p105,p50-Specific Polyclonal Antibody WB Human 7
23576-1-AP Human NFKB1 Polyclonal Antibody IF, IHC, WB Human 2
15503-1-AP Human NFKB2,p52,p100-Specific Polyclonal Antibody IHC, WB Human, Mouse 3
66920-1-Ig Human NFKB2 Monoclonal Antibody WB Human  
51085-1-AP Human NFKB2 Polyclonal Antibody WB Human, Mouse  
10409-2-AP Human NFKB2 Polyclonal Antibody IF, IHC, IP, WB Human, Mouse, Rat 13
CL594-66535 CL594-human NF-κB p65 Monoclonal Antibody IF Human, Rat  
CL488-66535 CL488-human NF-κB p65 Monoclonal Antibody IF Human, Rat  
10745-1-AP Human NF-κB p65 Polyclonal Antibody FC, IF, IHC, IP, WB Human, Mouse, Rat, Pig 741
66535-1-Ig Human NF-κB p65 Monoclonal Antibody IF, IHC, WB   86
66545-1-Ig Human STAT1 Monoclonal Antibody IHC, WB   8
10144-2-AP Human STAT1 Polyclonal Antibody FC, IF, IHC, IP, WB   70
66485-1-Ig Human STAT2 Monoclonal Antibody WB    
51075-2-AP Human STAT2 Polyclonal Antibody IHC, WB   1
16674-1-AP Human STAT2 Polyclonal Antibody IHC, IP, WB Human 9
14167-1-AP Human IRF9 Polyclonal Antibody IF, IHC, IP, WB Human, Mouse, Rat 11
23288-1-AP Human TRIF/TICAM1 Polyclonal Antibody IHC, WB Human 8
19851-1-AP Human TMEM173/STING Polyclonal Antibody FC, IF, IHC, IP, WB Human, Mouse, Rat 96
CL488-19851 CL488-Human TMEM173 Polyclonal Antibody IF Human  
66680-1-Ig Human TMEM173/STING Monoclonal Antibody IHC, WB Human, Rat  9
19771-1-AP Human NLRP3 Polyclonal Antibody WB Human 199
66902-1-Ig Human AIM2 Monoclonal Antibody WB Human, Mouse, Rat 2
11355-1-AP Human LGP2 PolyclonalAantibody IHC, IP, WB Human, Mouse, Rat 9
26416-1-AP Human C6orf150 Polyclonal Antibody IF, WB Human 17
25068-1-AP Human DDX58 Polyclonal Antibody IHC, IP, WB Human 1
20566-1-AP Human DDX58 Polyclonal Antibody IF, IP, WB Human, Mouse 18
CL488-21775 CL488-human IFIH1 Polyclonal Antibody IF Human, Mouse  
21775-1-AP Human IFIH1/MDA5 Polyclonal Antibody IHC, IP, WB Human 24
66770-1-Ig Human IFIH1/MDA5 Monoclonal Antibody IHC, WB Human 3
19816-1-AP Human TLR1 Polyclonal Antibody IHC Human, Mouse, Rat 1
66645-1-Ig Human TLR2 Monoclonal Antibody WB Human 4 
17766-1-AP Human TLR3 Polyclonal Antibody FC, IHC Human 7
66350-1-Ig Human TLR4 Monoclonal Antibody IHC, WB Human, Mouse, Rat, Pig 37
19811-1-AP Human TLR4 Polyclonal Antibody IHC, WB Human, Mouse, Rat 263
66570-1-Ig Human TLR5 Monoclonal Antibody WB Human, Pig, Mouse, Rat  
19810-1-AP Human TLR5 Polyclonal Antibody IHC, IP Human, Mouse 7
22240-1-AP Human TLR6 Polyclonal Antibody WB Human, Mouse 5
17232-1-AP Human TLR7 Polyclonal Antibody IHC, WB Human, Mouse, Rat 6
67317-1-Ig Human TLR8 Monoclonal Antibody IHC, WB Human   

 

カタログ番号 製品名 アプリケーション 交差種 文献数
FITC-65099 FITC-Human CD28 Monoclonal Antibody FC Human  
APC-65099 APC-Human CD28 Monoclonal Antibody FC Human  
PE-65099 PE-Human CD28 Monoclonal Antibody FC Human  
PE-65083 PE-Human CD80 (B7-1) Monoclonal Antibody FC Human  
14292-1-AP Human CD80/B7-1 Polyclonal Antibody FC, WB Human, Mouse 6
66406-1-Ig Human CD80/B7-1 Monoclonal Antibody IHC, WB Human, Mouse, Pig 10
26903-1-AP Human CD86 (C-terminal) Polyclonal Antibody WB Human 1
13395-1-AP Human CD86 Polyclonal Antibody FC, IF, WB Human 40

 

カタログ番号 製品名 アプリケーション 交差種 文献数
14955-1-AP Human OAS1 Polyclonal Antibody IF, IHC, WB Human, Mouse, Rat 13
19279-1-AP Human OAS2 Polyclonal Antibody IF, IHC, IP, WB Human, Mouse 13
21915-1-AP Human OAS3 Polyclonal Antibody WB. IHC, IF Human 6

 

カタログ番号 製品名 アプリケーション 交差種 文献数
10852-1-AP Human CLTA Polyclonal Antibody IF, IHC, IP, WB Human, Mouse, Rat 14
11727-3-AP Human IFITM1 Polyclonal Antibody FC, IHC, IP, WB Human 22
60074-1-Ig Human IFITM1-Specific Monoclonal Antibody IHC, IP, WB Human, Rat 48
66081-1-Ig Human IFITM2/3 Monoclonal Antibody FC, IF, IHC, WB Human 12
11714-1-AP Human IFITM3 Polyclonal Antibody FC, IF, IHC, IP, WB Human, Mouse, Rat 87
12769-1-AP Human IFITM2 Polyclonal Antibody IF, IHC, IP, WB Human 33
66137-1-Ig Human IFITM2-specific Monoclonal Antibody FC, WB Human 106
22144-1-AP Human LY6E Polyclonal Antibody WB, IHC, ELISA Human, Mouse 2
29270-1-AP TMEM41B Polyclonal antibody WB, IHC, ELISA Human, Mouse 2
20768-1-AP TMEM41A Polyclonal antibody WB, ELISA Human, Mouse, Rat 3
20489-1-AP DAXX Polyclonal antibody WB, IF, ELISA Human, Mouse 2
67879-1-Ig DAXX Monoclonal antibody WB, IHC, IF, ELISA Human  
Ag14606 DAXX Fusion      

 

カタログ番号 製品名 アプリケーション 交差種 文献数
10794-1-AP Human MTHFD1 Polyclonal Antibody WB, IP, IHC, ELISA Human, Mouse 9
11246-1-AP Human G1P3 Polyclonal Antibody IHC Human 1
12604-1-AP Human IFIT2 Polyclonal Antibody IF, IHC, IP, WB Human, Mouse 31
23247-1-AP Human IFIT1 Polyclonal Antibody IHC, WB Human, Mouse, Rat 13
67208-1-Ig Human IFIT3 Monoclonal Antibody IHC, WB Human  
15201-1-AP Human IFIT3 Polyclonal Antibody IF, IHC, IP, WB Human 13 
66646-1-Ig Human EIF2AK2 Monoclonal Antibody IHC, WB Human  
18244-1-AP Human EIF2AK2, PKR Polyclonal Antibody IF, IHC, IP, WB, Human, Mouse, Rat 17
15981-1-AP Human ISG15 Polyclonal Antibody IF, IHC, IP, WB Human 27
13378-1-AP Human IFIT5 Polyclonal Antibody IHC, IP, WB Human 5
27865-1-AP Human RyDEN Polyclonal Antibody WB Human, Mouse, Rat 2
13750-1-AP Human MX1 Polyclonal Antibody IF, IHC, IP, WB Human, Mouse 68
66413-1-Ig Human ZC3HAV1 Monoclonal Antibody IF, IHC, WB Human 1
CL594-66413 CL594-Human ZC3HAV1 Monoclonal Antibody IF Human  
CL488-66413 CL488-Human ZC3HAV1 Monoclonal Antibody IF Human  
16820-1-AP Human ZC3HAV1 Polyclonal Antibody IHC, IP, WB Human, Mouse, Rat 24
17535-1-AP Human PARP9 Polyclonal Antibody IHC, IP, WB Human, Rat 4
28089-1-AP Human RSAD2 Polyclonal Antibody WB Human 3
11963-1-AP Human DTX3L Polyclonal Antibody WB Human 2

 

カタログ番号 製品名 アプリケーション 交差種 文献数
12216-1-AP Human Cathepsin B Polyclonal Antibody FC, IF, IHC, WB Human, Mouse 30
14437-1-AP Human TMPRSS2 Polyclonal Antibody IHC, WB Human, Mouse, Rat 15  

 

カタログ番号 製品名 アプリケーション 交差種 文献数
13744-1-AP Human TRIM22 Polyclonal Antibody IHC, WB Human, Mouse 3
10326-1-AP Human TRIM32 Polyclonal Antibody IF, IHC, WB Human, Mouse, Rat 10
10851-1-AP Human TRIM11 Polyclonal Antibody IHC, WB Human 9
11476-1-AP Human TRIM5 Polyclonal Antibody WB Human, Mouse  
67492-1-Ig Human TRIM5 Monoclonal Antibody WB Human  
13623-1-AP Human TRIM15 Polyclonal Antibody IF, WB Human, Mouse 4 

 

カタログ番号 製品名 アプリケーション 交差種 文献数
25404-1-AP Human CD209 Polyclonal Antibody WB, FC Human 1
17699-1-AP Human ICAM3 Polyclonal Antibody WB, IP, IHC, FC Human  
22003-1-AP Human CLEC4M Polyclonal Antibody IHC Human  
10253-2-AP Human STAT3 Polyclonal Antibody WB, IP, IHC, IF, FC, CoIP, ChIP Human, Mouse, Rat, Marmoset 212
60199-1-Ig Human STAT3 Monoclonal Antibody WB, IP, IHC, IF Human, Mouse, Rat 25
15613-1-AP Human Fibronectin Polyclonal Antibody WB, IP, IF Human, Mouse, Rat, Porcine 321
66042-1-Ig Human Fibronectin Monoclonal Antibody WB, IP, IHC, IF Human, Mouse, Rat 32
66415-1-Ig Human AGTR1 Monoclonal Antibody WB Human, Mouse, Rat, Pig  
25343-1-AP Human AGTR1 Polyclonal Antibody WB, IHC, IF Human, Mouse, Rat 29
12636-1-AP Human FAK Polyclonal Antibody WB, IP, IHC, IF Human, Mouse, Rat 51
66258-1-Ig Human FAK Monoclonal Antibody WB, IHC, IF Human, Mouse, Rat 21
11992-1-AP Human Angiotensinogen Polyclonal Antibody WB, IHC, FC Human, Mouse 14
14291-1-AP Human Renin Polyclonal Antibody WB, IHC, IF Human, Mouse, Rat 15
13083-1-AP Human IFNAR1 Polyclonal Antibody WB, IF, FC Human 4
10522-1-AP Human IFNAR2 Polyclonal Antibody WB, FC Human 2

 

SARS-CoV-2の侵入と嗅覚障害について—Bilinska, -et al.著（ACS Chemical Neuroscience誌に掲載されました）

Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age（嗅上皮細胞におけるSARS-CoV-2が感染に用いるタンパク質、ACE2およびTMPRSS2の発現について：細胞の種類の同定および年齢傾向 ）（PMID：32379417）

Summary provided by Rafal Butowt, PhD, Department of Molecular Cell Genetics, L. Rydygier Collegium Medicum, Nicolaus Copernicus University (Poland), corresponding author.

In the current coronavirus pandemic, a relatively large number of patients have a total loss (anosmia) or deficit of smell (hyposmia), but the mechanism is unknown. Using a mouse model, we showed that cells in the olfactory epithelium lying within the nasal cavity express host receptors that enable the SARS-CoV-2 virus to enter and infect selected cells. We identified these cells as sustentacular cells which are located near olfactory receptor neuronal dendrites containing odorant receptors. These cells are metabolically coupled with olfactory receptor neurons, participating in detoxification, odorant-desensitization and as an energy supplier to the olfactory neurons. Thus, SARS-CoV-2 infection of sustentacular cells could explain the olfactory deficient phenotype in COVID-19 patients. We also show that some proteins important for SARS-CoV-2 entry are at higher levels in older mice olfactory epithelium than in younger mice. It is speculated that sustentacular cells in the olfactory epithelium may contain more SARS-CoV-2 viral particle than cells in the oral cavity, making it easier to detect people that are infected with the virus.

Butowt and colleagues used Proteintech’s ACE2 antibody (21115-1-AP) to detect expression of the target in olfactory tissue throughout the study. Proteintech’s HSP25 antibody (18284-1-AP) was used to mark sustentacular cells of the olfactory epithelium.

Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures （ヒト気道および結膜におけるSARS-CoV-2コロナウイルスの指向性、複製能、自然免疫応答：ex-vivoおよびin-vitro培養解析）

Pathogenesis of SARS-CoV-2 in human respiratory tract and conjunctiva. Research published in The Lancet Respiratory Medicine featuring Proteintech’s CC10/Uteroglobin (10490-1-AP).

Orthogonal genome-wide screenings in bat cells identify MTHFD1 as a target of 2 broad antiviral therapy （コウモリ細胞オーソログ領域ゲノムワイドスクリーニングによる2種類のウイルス感染症の治療ターゲットMTHFD1の同定）

MTHFD1 Antibody (10794-1-AP) - Anderson et al.

No evidence that androgen regulation of pulmonary TMPRSS2 explains sex-discordant COVID-19 outcomes （アンドロゲンによる肺TMPRSS2の調節がCOVID-19転帰の性差の原因であるとする根拠は認められない）

TMPRSS2 Antibody (14437-1-AP) – Baratchian et al.

LY6E Restricts Entry of Human Coronaviruses, Including Currently Pandemic SARS-CoV-2 （パンデミック継続中のヒトSARS-CoV-2等ヒトコロナウイルスのLY6Eによる侵入制限）

LY6E Antibody (22144-1-AP) - Zhao et al

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